Article
Altered DNA methylation associated with an abnormal liver phenotype in a cattle model with a high incidence of perinatal pathologies.
Scientific reports - 13 Dec 2016
Kiefer Hélène, Jouneau Luc, Campion Évelyne, Rousseau-Ralliard Delphine, Larcher Thibaut, Martin-Magniette Marie-Laure, Balzergue Sandrine, Ledevin Mireille, Prézelin Audrey, Chavatte-Palmer Pascale, Heyman Yvan, Richard Christophe, Le Bourhis Daniel, Renard Jean-Paul, Jammes Hélène
Abstract excerpt
Cloning enables the generation of both clinically normal and pathological individuals from the same donor cells, and may therefore be a DNA sequence-independent driver of phenotypic variability. We took advantage of cattle clones with identical genotypes but different developmental abilities to investigate the role of epigenetic factors in perinatal mortality, a complex trait with increasing prevalence in dairy...
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