Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MTHFD1 gene is not involved in cleft lip with or without palate onset among the Italian population.

Annals of human genetics - 1 May 2008

Palmieri A, Masiero E, Martinelli M, Scapoli L, Pezzetti F, Caramelli E, Guidotti L, Carinci F

Abstract excerpt

Nonsyndromic cleft lip with or without cleft palate (CL/P) is the most common orofacial malformation, having a non-Mendelian and multifactorial aetiology. It has been shown that polymorphic variants of genes encoding key proteins of folate and methionine metabolism might be important maternal risk factors for having a child with these craniofacial anomalies. The aim of this study was to evaluate the role of two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cleft Lip
Share to Cleft Palate
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Linkage Disequilibrium

Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

Share to White People

Source

Identifiers

PMID: 18261183
DOI: 10.1111/j.1469-1809.2007.00428.x

Genes

MTHFD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MTHFD1 gene is not involved in cleft lip with or without palate onset among the Italian population.PMID 18261183Read ↗

Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate.Semantic proximity Read ↗

Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations.Semantic proximity Read ↗

Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population.Semantic proximity Read ↗

Significant association of MTHFD1 1958G>A single nucleotide polymorphism with nonsyndromic cleft lip and palate in Indian population.Semantic proximity Read ↗

RFC1 and non-syndromic cleft lip with or without cleft palate: an association based study in Italy.Semantic proximity Read ↗

Association Between MTHFD1 1958G > A Variant and non-Syndromic Cleft lip and Palate: An Updated Meta-Analysis.Semantic proximity Read ↗

Evidence of LEF1 fetal-maternal interaction in cleft lip with or without cleft palate in a consistent Italian sample study.Semantic proximity Read ↗

NEW INSIGHTS IN OROFACIAL CLEFT: EPIDEMIOLOGICAL AND GENETIC STUDIES ON ITALIAN SAMPLESSemantic proximity Read ↗

Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from central Europe.Semantic proximity Read ↗

C677T variant form at the MTHFR gene and CL/P: a risk factor for mothers?Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphisms and risk of nonsyndromic orofacial clefts in a south Indian population.Semantic proximity Read ↗

Cystathionine beta-synthase c.844ins68 gene variant and non-syndromic cleft lip and palate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.