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Article

Evidence of LEF1 fetal-maternal interaction in cleft lip with or without cleft palate in a consistent Italian sample study.

International journal of immunopathology and pharmacology - 1 Jan 2000

Martinelli M, Carinci F, Morselli P G, Caramelli E, Palmieri A, Girardi A, Riberti C, Scapoli L

Abstract excerpt

Epithelial mesenchymal transformation is considered a cardinal process in orofacial development. Several molecular players appear to be involved in this delicate mechanism; the activation of LEF1 transcription factor by transforming growth factor beta 3 seems to be a key step for the correct flow of events. The failure of orofacial processes during embryonic development may provoke cleft lip and/or cleft palate...

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PMID: 21781440
DOI: 10.1177/03946320110240S204

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CPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence of LEF1 fetal-maternal interaction in cleft lip with or without cleft palate in a consistent Italian sample study.PMID 21781440Read ↗

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Orofacial clefting: update on the role of genetics.Semantic proximity Read ↗

The MTHFD1 gene is not involved in cleft lip with or without palate onset among the Italian population.Semantic proximity Read ↗

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