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Article

TMC1 but not TMC2 is responsible for autosomal recessive nonsyndromic hearing impairment in Tunisian families.

Audiology & neuro-otology - 1 Jan 2008

Tlili Abdelaziz, Rebeh Imen Ben, Aifa-Hmani Mounira, Dhouib Houria, Moalla Jihen, Tlili-Chouchène Jihen, Said Mariem Ben, Lahmar Imed, Benzina Zeineb, Charfedine Ilhem, Driss Nabil, Ghorbel Abdelmonem, Ayadi Hammadi, Masmoudi Saber

Abstract excerpt

Hereditary nonsyndromic hearing impairment (HI) is extremely heterogeneous. Mutations of the transmembrane channel-like gene 1 (TMC1) have been shown to cause autosomal dominant and recessive forms of nonsyndromic HI linked to the loci DFNA36 and DFNB7/B11, respectively. TMC1 is 1 member of a fam...

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Source

Identifiers

PMID: 18259073
DOI: 10.1159/000115430

Genes

TMC1
TMC2
GJB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18259073-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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TMC1 but not TMC2 is responsible for autosomal recessive nonsyndromic hearing impairment in Tunisian families.PMID 18259073Read ↗

Identification of TMC1 as a relatively common cause for nonsyndromic hearing loss in the Saudi population.Semantic proximity Read ↗

Mutation analysis of TMC1 identifies four new mutations and suggests an additional deafness gene at loci DFNA36 and DFNB7/11.Semantic proximity Read ↗

Genetic and clinical aspects of TMC1-related hearing loss in Iranian families: identification of two novel variants.Semantic proximity Read ↗

A novel mutation in the TMC1 gene causes non-syndromic hearing loss in a Moroccan family.Semantic proximity Read ↗

Prevalence and clinical features of autosomal dominant and recessive TMC1-associated hearing loss.Semantic proximity Read ↗

A TMC1 (transmembrane channel-like 1) mutation (p.S320R) in a Polish family with hearing impairment.Semantic proximity Read ↗

Prevalence and Clinical Features of Autosomal Dominant and Recessive TMC1-Associated Hearing Loss.Semantic proximity Read ↗

Mutations in TMC1 contribute significantly to nonsyndromic autosomal recessive sensorineural hearing loss: a report of five novel mutations.Semantic proximity Read ↗

Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction.Semantic proximity Read ↗

A transversion mutation in non-coding exon 3 of the TMC1 gene in two ethnically related Iranian deaf families from different geographical regions; evidence for founder effect.Semantic proximity Read ↗

Identification of a novel homozygous mutation in transmembrane channel like 1 (TMC1) gene, one of the second-tier hearing loss genes after GJB2 in India.Semantic proximity Read ↗

A novel DFNA36 mutation in TMC1 orthologous to the Beethoven (Bth) mouse associated with autosomal dominant hearing loss in a Chinese family.Semantic proximity Read ↗

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