Article
A transversion mutation in non-coding exon 3 of the TMC1 gene in two ethnically related Iranian deaf families from different geographical regions; evidence for founder effect.
International journal of pediatric otorhinolaryngology - 1 May 2013
Davoudi-Dehaghani Elham, Zeinali Sirous, Mahdieh Nejat, Shirkavand Atefeh, Bagherian Hamideh, Tabatabaiefar Mohammad Amin
Abstract excerpt
OBJECTIVES: Transmembrane channel-like 1 (TMC1) gene is a member of the transmembrane channel-like (TMC) gene family that encodes an integral membrane protein of the inner ear. It is suggested that mutation in this gene is one of the main causes of autosomal recessive non-syndromic hearing loss (ARNSHL) in different populations. The aim of this study was to determine the contribution of the TMC1 gene mutations in...
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