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Article

Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients.

Genes and immunity - 1 Jan 2003

Zhang Y, Syed R, Uygar C, Pallos D, Gorry M C, Firatli E, Cortelli J R, VanDyke T E, Hart P S, Feingold E, Hart T C

Abstract excerpt

Polymorphonuclear neutrophils (PMNs) are attracted to sites of infection by N-formylpeptide (fMLP) chemoattractants. The high-affinity fMLP receptor (FPR1) of phagocytic cells interacts with bacterial fMLP and mediates chemotaxis, degranulation, and superoxide production. These cellular functions are disrupted in PMN from aggressive periodontitis (AP) patients. Two FPR1 gene single nucleotide polymorphisms...

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Source

Identifiers

PMID: 12595898
DOI: 10.1038/sj.gene.6363900

Genes

FPR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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