Article

Wnt-Activated Immunoregulatory Myeloid Cells Prevent Relapse in Experimental Autoimmune Encephalomyelitis and Offer a Potential Therapeutic Strategy for Multiple Sclerosis

2025-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by recurrent inflammatory relapses and neurodegeneration. Myeloid cells play a critical role in shaping the inflammatory environment and influencing disease progression. Here, we demonstrate that activation of the Wnt signaling pathway reprograms myeloid cells into an immunoregulatory phenot...

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Literature Corpus work: 49534e3b-1840-5f39-8982-7995443b75fc
DOI: 10.1101/2025.02.16.638560

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