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Article

Early Malignant Progression of Hereditary Medullary Thyroid Cancer

15 Oct 2003

Abstract excerpt

BACKGROUND: An age-related progression from C-cell hyperplasia to medullary thyroid carcinoma is associated with various germ-line mutations in the rearranged during transfection (RET) proto-oncogene that could be used to identify the optimal time for prophylactic surgery. METHODS: In this European multicenter study conducted from July 1993 to February 2001, we enrolled patients who had a RET point mutation in...

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Share to Thyroid and Parathyroid Surgery
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Identifiers

PMID: 14561794
DOI: 10.1056/nejmoa012915

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When is prophylactic thyroidectomy indicated for patients with the RET codon 609 mutation?Semantic proximity Read ↗

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