Article
Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesis.
The Biochemical journal - 1 May 2008
Ismail Nurzian, Crawshaw Samuel G, Cross Benedict C S, Haagsma Anna C, High Stephen
Abstract excerpt
A site-specific cross-linking approach was used to study the integration of TM (transmembrane) segments 4-7 of the polytopic membrane protein, opsin, at the ER (endoplasmic reticulum). We found that although TM4 exits the ER translocon rapidly, TM segments 5, 6 and 7 are all retained at the translocon until opsin biosynthesis is terminated. Furthermore, although artificial extension of the nascent chain is not...
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