Discovery of Chromone‐Based Inhibitors of the Transcription Factor STAT5

Abstract excerpt

Obstacles overcome: Gene-specific transcription factors are emerging therapeutic targets, but their direct inhibition is considered to be difficult because of the absence of enzymatic activities. This manuscript describes the discovery of chromone-based inhibitors of the protein–protein interactions required for activity of the transcription factor STAT5, a therapeutic target for the treatment of human cancers.

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