Article
An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women.
Human genetics - 1 Apr 2008
Stanisławska-Sachadyn Anna, Brown Karen S, Mitchell Laura E, Woodside Jayne V, Young Ian S, Scott John M, Murray Liam, Boreham Colin A, McNulty Helene, Strain J J, Whitehead Alexander S
Abstract excerpt
A low serum folate and high homocysteine phenotype is associated with an increased risk of neural tube defects (NTDs), cardiovascular diseases and other pathologies. Thus defining both genetic and non-genetic factors that may impact folate/homocysteine metabolism will enhance our understanding of the etiologic mechanisms underlying these conditions and facilitate risk assessment. Dihydrofolate reductase catalyzes...
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