Article
Use of short sequence repeat DNA polymorphisms after PCR amplification to detect the parental origin of the additional chromosome 21 in Down syndrome.
American journal of human genetics - 1 Jan 1991
Petersen M B, Schinzel A A, Binkert F, Tranebjaerg L, Mikkelsen M, Collins F A, Economou E P, Antonarakis S E
Abstract excerpt
The origin of nondisjunction in trisomy 21 has so far been studied using cytogenetic heteromorphisms and DNA polymorphisms using Southern blot analysis. Short sequence repeats have recently been described as an abundant class of DNA polymorphisms in the human genome, which can be typed using the...
Topics
- Alleles
- Chromosomes, Human, Pair 21
- DNA
- Down Syndrome
- Female
- Heterozygote
- Humans
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic