Article
Fluorescence microsatellite analysis to study the parental origin of the supernumerary chromosome in Down's syndrome.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics - 1 May 1998
Ko T M, Hwa H L, Tseng L H, Lin Y W, Cheung Y P
Abstract excerpt
OBJECTIVE: Down's syndrome (DS) is an important cause of mental retardation. This study investigated the parental origin of the extra chromosome 21 in DS patients. METHODS: Fourteen families each with a DS patient were recruited for analysis of nine microsatellite markers on chromosome 21. We col...
Topics
- Adult
- Alleles
- Down Syndrome
- Female
- Fluorescence
- Humans
- Microsatellite Repeats
- Polymerase Chain Reaction
- Polymorphism, Genetic