Article
Fluorescence microsatellite analysis to study the parental origin of the supernumerary chromosome in Down's syndrome.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics - 1 May 1998
Ko T M, Hwa H L, Tseng L H, Lin Y W, Cheung Y P
Abstract excerpt
OBJECTIVE: Down's syndrome (DS) is an important cause of mental retardation. This study investigated the parental origin of the extra chromosome 21 in DS patients. METHODS: Fourteen families each with a DS patient were recruited for analysis of nine microsatellite markers on chromosome 21. We collected DNA from both parents and the patient and used polymerase chain reaction to amplify nine segments on chromosome...
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