Article
Linkage mapping of the highly informative DNA marker D21S156 to human chromosome 21 using a polymorphic GT dinucleotide repeat.
Genomics - 1 Oct 1990
Lewis J G, Weber J L, Petersen M B, Slaugenhaupt S A, Kwitek A, May P E, Warren A C, Chakravarti A, Antonarakis S E
Abstract excerpt
A (GT)n repeat within the anonymous DNA sequence D21S156 was shown to be highly polymorphic in DNA from members of the 40 CEPH families. At least 12 alleles of this locus were recognized by electrophoresis on polyacrylamide gels of DNA amplified by the polymerase chain reaction (PCR) using primers flanking the (GT)n repeat. The polymorphism information content was 0.82. PCR amplification of DNA from somatic cell...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Genetic Markers
- Humans
- Lod Score
- Molecular Sequence Data
- Pedigree
- Polymorphism, Restriction Fragment Length