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Article

Independent effects of cis- and trans-regulatory variation on gene expression in Drosophila melanogaster.

Genetics - 1 Mar 2008

Wittkopp Patricia J, Haerum Belinda K, Clark Andrew G

Abstract excerpt

Biochemical interactions between cis-regulatory DNA sequences and trans-regulatory gene products suggest that cis- and trans-acting polymorphisms may interact genetically. Here we present a strategy to test this hypothesis by comparing the relative cis-regulatory activity of two alleles in different genetic backgrounds. Of the eight genes surveyed in this study, five were affected by trans-acting variation that...

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Identifiers

PMID: 18245838
DOI: 10.1534/genetics.107.082032
PMCID: PMC2278090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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