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Multiparent recombinant inbred lines crossed to a tester provide novel insights into sources of cis and trans regulation of gene expression.

Genetics - 4 Feb 2026

Marroni Fabio, Morse Alison M, Nanni Adalena V, Nolte Nadja, Williams-Simon Patricka, León-Novelo Luis G, Graze Rita M, Schmidt Paul, King Elizabeth, McIntyre Lauren M

Abstract excerpt

To understand the relative importance of cis and trans effects on regulation, we crossed multi-parent recombinant-inbred lines (RILs) to a common tester and measured allele-specific gene expression in the offspring. Testing the difference of allelic imbalance between two RIL × Tester crosses is a test of cis or trans, depending on the RIL alleles compared. The study design also enables to separation of two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41308074
DOI: 10.1093/genetics/iyaf257
PMCID: PMC13112460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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