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Enhancement of <i>in vitro</i> and <i>in vivo</i> tumor cell radiosensitivity by valproic acid

1 Dec 2004

Abstract excerpt

Valproic acid (VA) is a well-tolerated drug used to treat seizure disorders and has recently been shown to inhibit histone deacetylase (HDAC). Because HDAC modulates chromatin structure and gene expression, parameters considered to influence radioresponse, we investigated the effects of VA on the radiosensitivity of human brain tumor cells grown in vitro and in vivo. The human brain tumor cell lines SF539 and...

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PMID: 15578701
DOI: 10.1002/ijc.20774

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