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Article

ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer

1 Aug 2013

Abstract excerpt

Chromosomal translocations juxtaposing the androgen-responsive TMPRSS2 promoter with the ETS-family transcription factor ERG result in aberrant ERG upregulation in approximately 50% of prostate cancers. Studies to date have shown important roles of ERG in inducing oncogenic properties of prostate cancer. Its molecular mechanisms of action, however, are yet to be fully understood. Here, we report that ERG...

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PMID: 23913826
DOI: 10.1158/0008-5472.can-13-0882

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ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate CancerPMID 23913826Read ↗

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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.Semantic proximity Read ↗

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ERG orchestrates chromatin interactions to drive prostate cell fate reprogrammingSemantic proximity Read ↗

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