Article
Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency.
Mutation research - 2 Apr 2008
Taira Kentaro, Nakamura Shintaro, Nakano Khota, Maehara Daisuke, Okamoto Keinosuke, Arimoto Sakae, Loakes David, Worth Leroy, Schaaper Roel M, Seio Kohji, Sekine Mitsuo, Negishi Kazuo, Negishi Tomoe
Abstract excerpt
The MutS-based mismatch repair (MMR) system has been conserved from prokaryotes to humans, and plays important roles in maintaining the high fidelity of genomic DNA. MutS protein recognizes several different types of modified base pairs, including methylated guanine-containing base pairs. Here, we looked at the relationship between recognition and the effects of methylating versus ethylating agents on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.