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Origins of Waldenstrom's macroglobulinemia: does it arise from an unusual B-cell precursor?

Clinical lymphoma - 1 Mar 2005

Kriangkum Jitra, Taylor Brian J, Reiman Tony, Belch Andrew R, Pilarski Linda M

Abstract excerpt

Clonotypic B cells of Waldenstrom's macroglobulinemia (WM) are CD20+ immunoglobulin (Ig) M+ IgD+ cells that lack ongoing somatic hypermutation and class switch recombination (CSR). Only a small compartment of clonotypic B cells express activation-induced cytosine deaminase. Activation by CD40L/interleukin-4 does not stimulate WM class switching. However, we found that the mutation of switch regions essential for...

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Identifiers

PMID: 15794851
DOI: 10.3816/clm.2005.n.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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