Article
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.
Gastroenterology - 1 Feb 2008
Sun Xun, Somada Shinichi, Shibata Kensuke, Muta Hiromi, Yamada Hisakata, Yoshihara Hirofumi, Honda Kuniomi, Nakamura Kazuhiko, Takayanagi Ryhoichi, Tani Kenzaburo, Podack Eckhard R, Yoshikai Yasunobu
Abstract excerpt
BACKGROUND & AIMS: A CD30-ligand (CD30L) is a 40-kilodalton, type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. Serum levels of soluble CD30 increased in inflammatory bowel diseases (IBD), suggesting that CD30L/CD30 signaling is involved in the pathogenesis of IBD. In this study, we investigated the role of CD30L in oxazolone (OXA)- and trinitrobenzene sulfonic acid...
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