Article
Serum levels of soluble CD30 are increased in ulcerative colitis (UC) but not in Crohn's disease (CD).
Clinical and experimental immunology - 1 Mar 1998
Giacomelli R, Passacantando A, Parzanese I, Vernia P, Klidara N, Cucinelli F, Lattanzio R, Santori E, Cipriani P, Caprilli R, Tonietti G
Abstract excerpt
Imbalance in Th1 and Th2 subsets and their derived cytokines seems to be involved in the immune abnormalities underlying UC and CD. CD30 is a member of the tumour necrosis factor/nerve growth receptor superfamily expressed on T cells producing Th2 cytokines and released as a soluble form. In this study high levels of soluble CD30 were found in sera of UC patients independently of disease activity. Furthermore,...
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