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Article

Wild type measles virus attenuation independent of type I IFN.

Virology journal - 3 Feb 2008

Druelle Johan, Sellin Caroline I, Waku-Kouomou Diane, Horvat Branka, Wild Fabian T

Abstract excerpt

BACKGROUND: Measles virus attenuation has been historically performed by adaptation to cell culture. The current dogma is that attenuated virus strains induce more type I IFN and are more resistant to IFN-induced protection than wild type (wt). RESULTS: The adaptation of a measles virus isolate (G954-PBL) by 13 passages in Vero cells induced a strong attenuation of this strain in vivo. The adapted virus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18241351
DOI: 10.1186/1743-422X-5-22
PMCID: PMC2275253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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