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Article

Adaptation to cell culture induces functional differences in measles virus proteins.

Virology journal - 27 Oct 2008

Bankamp Bettina, Fontana Judith M, Bellini William J, Rota Paul A

Abstract excerpt

BACKGROUND: Live, attenuated measles virus (MeV) vaccine strains were generated by adaptation to cell culture. The genetic basis for the attenuation of the vaccine strains is unknown. We previously reported that adaptation of a pathogenic, wild-type MeV to Vero cells or primary chicken embryo fibroblasts (CEFs) resulted in a loss of pathogenicity in rhesus macaques. The CEF-adapted virus (D-CEF) contained single...

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Source

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Identifiers

PMID: 18954437
DOI: 10.1186/1743-422X-5-129
PMCID: PMC2582235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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