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Article

Enhanced XPA mRNA levels in cisplatin-resistant human ovarian cancer are not associated with XPA mutations or gene amplification.

Cancer letters - 29 Nov 1996

States J C, Reed E

Abstract excerpt

Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells is often caused by mutations or gene amplification. Molecular analyses of the XPA genes in human...

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Source

Identifiers

PMID: 8973600
DOI: 10.1016/s0304-3835(96)04428-x

Genes

XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhanced XPA mRNA levels in cisplatin-resistant human ovarian cancer are not associated with XPA mutations or gene amplification.PMID 8973600Read ↗

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DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell linesSemantic proximity Read ↗

Expression of a splicing variant in the 5'-UTR of the human ERCC1 gene is not cancer related.Semantic proximity Read ↗

Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cellsSemantic proximity Read ↗

Expression of DNA repair genes in ovarian cancer samples: Biological and clinical considerationsSemantic proximity Read ↗

Functional characterization of EMSY gene amplification in human cancersSemantic proximity Read ↗

Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancerSemantic proximity Read ↗

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