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Article

Association between ERCC1 and XPA expression and polymorphisms and the response to cisplatin in testicular germ cell tumours.

British journal of cancer - 9 Jul 2013

Mendoza J, Martínez J, Hernández C, Pérez-Montiel D, Castro C, Fabián-Morales E, Santibáñez M, González-Barrios R, Díaz-Chávez J, Andonegui M A, Reynoso N, Oñate L F, Jiménez M A, Núñez M, Dyer R, Herrera L A

Abstract excerpt

BACKGROUND: Cisplatin cures over 80% of testicular germ cell tumours (TGCTs), and nucleotide-excision repair (NER) modifies the sensitivity to cisplatin. We explored the association between NER proteins and their polymorphisms with cisplatin sensitivity (CPS) and overall survival (OS) of patients with non-seminomatous (ns)-TGCTs. METHODS: The expression of ERCC1 and XPA and the presence of γH2AX were evaluated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

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Source

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Identifiers

PMID: 23807173
DOI: 10.1038/bjc.2013.303
PMCID: PMC3708571

Genes

ERCC1
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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