Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study.

doi:10.1038/oby.2007.21

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Article

Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study.

Obesity (Silver Spring, Md.) - 1 Feb 2008

Heid Iris M, Vollmert Caren, Kronenberg Florian, Huth Cornelia, Ankerst Donna P, Luchner Andreas, Hinney Anke, Brönner Günter, Wichmann H-E, Illig Thomas, Döring Angela, Hebebrand Johannes

Abstract excerpt

OBJECTIVE: Epidemiological studies showing an association between the melanocortin-4-receptor (MC4R) 103I variant (rs2229616) and decreased BMI are complemented by functional studies; these suggest a mechanism for appetite regulation and a linkage signal for physical activity and dietary intake for the region encompassing the MC4R. This study aims to provide epidemiological evidence for showing the association of...

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PMID: 18239646
DOI: 10.1038/oby.2007.21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study.PMID 18239646Read ↗

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Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons.Semantic proximity Read ↗

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals.Semantic proximity Read ↗

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The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels.Semantic proximity Read ↗

Melanocortin-4 receptor gene variant I103 is negatively associated with obesity.Semantic proximity Read ↗

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.Semantic proximity Read ↗

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.Semantic proximity Read ↗

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.Semantic proximity Read ↗

Dietary quality indices modifies the effects of melanocortin-4 receptor (MC4R) rs17782313 polymorphism on cardio-metabolic risk factors and hypothalamic hormones in obese adults.Semantic proximity Read ↗

Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals.Semantic proximity Read ↗

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