Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study.

Obesity (Silver Spring, Md.) - 1 Feb 2008

Heid Iris M, Vollmert Caren, Kronenberg Florian, Huth Cornelia, Ankerst Donna P, Luchner Andreas, Hinney Anke, Brönner Günter, Wichmann H-E, Illig Thomas, Döring Angela, Hebebrand Johannes

Abstract excerpt

OBJECTIVE: Epidemiological studies showing an association between the melanocortin-4-receptor (MC4R) 103I variant (rs2229616) and decreased BMI are complemented by functional studies; these suggest a mechanism for appetite regulation and a linkage signal for physical activity and dietary intake for the region encompassing the MC4R. This study aims to provide epidemiological evidence for showing the association of...

Topics

Adult
Appetite Regulation
Body Mass Index
Body Size
Cross-Sectional Studies
Energy Metabolism
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germany

Humans

Male

Metabolic Syndrome

Middle Aged

Models, Statistical

Obesity

Polymorphism, Single Nucleotide

Receptor, Melanocortin, Type 4

Source

Identifiers

PMID: 18239646
DOI: 10.1038/oby.2007.21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study.PMID 18239646Read ↗

Association of the 103I <i>MC4R</i> allele with decreased body mass in 7937 participants of two population based surveysSemantic proximity Read ↗

Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons.Semantic proximity Read ↗

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals.Semantic proximity Read ↗

An Association between Diet and MC4R Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters-A Cross Sectional Population-Based Study.Semantic proximity Read ↗

The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels.Semantic proximity Read ↗

Melanocortin-4 receptor gene variant I103 is negatively associated with obesity.Semantic proximity Read ↗

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.Semantic proximity Read ↗

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.Semantic proximity Read ↗

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.Semantic proximity Read ↗

Dietary quality indices modifies the effects of melanocortin-4 receptor (MC4R) rs17782313 polymorphism on cardio-metabolic risk factors and hypothalamic hormones in obese adults.Semantic proximity Read ↗

Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.