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Article

Analysis of the thermodynamics of binding of an SH3 domain to proline-rich peptides using a chimeric fusion protein.

Journal of molecular biology - 14 Mar 2008

Candel Adela M, van Nuland Nico A J, Martin-Sierra Francisco M, Martinez Jose C, Conejero-Lara Francisco

Abstract excerpt

A complete understanding of the thermodynamic determinants of binding between SH3 domains and proline-rich peptides is crucial to the development of rational strategies for designing ligands for these important domains. Recently we engineered a single-chain chimeric protein by fusing the alpha-spectrin Src homology region 3 (SH3) domain to the decapeptide APSYSPPPPP (p41). This chimera mimics the structural and...

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Identifiers

PMID: 18234212
DOI: 10.1016/j.jmb.2007.11.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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