Interindividual variability in acetaminophen sulfation by human fetal liver: Implications for pharmacogenetic investigations of drug‐induced birth defects

Abstract excerpt

BACKGROUND: Acetaminophen (APAP) use in early pregnancy has been associated with the risk of gastroschisis, a rare but serious congenital defect of the abdominal wall. The purpose of this study was to characterize the variability of APAP sulfation in a panel of human fetal livers and to identify the sulfotransferases (SULT) isoform(s) responsible for catalyzing that activity. METHODS: APAP sulfation was...

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