Article
Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21.
Anatomical record (Hoboken, N.J. : 2007) - 1 Mar 2008
Sebrié Catherine, Chabert Caroline, Ledru Aurélie, Guedj Fayçal, Po Chrystelle, Smith Desmond J, Rubin Edward, Rivals Isabelle, Beloeil Jean-Claude, Gillet Brigitte, Delabar Jean-Maurice
Abstract excerpt
A yeast artificial chromosome (YAC) transgenic murine model of partial trisomy 21 overexpressing five human genes -- including DYRK1A, which encodes a serine threonine kinase involved in cell cycle control -- has been shown to present an increase in brain weight. We analyzed this new phenotype by measuring total and regional brain volumes at different ages, using a 7 Tesla magnetic resonance imaging volumetric...
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