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Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

25 Feb 2009

Abstract excerpt

Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that...

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PMID: 19242551
DOI: 10.1371/journal.pone.0004606

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