Article
Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.
Journal of neuropathology and experimental neurology - 1 May 2004
Branchi Igor, Bichler Zoë, Minghetti Luisa, Delabar Jean Maurice, Malchiodi-Albedi Fiorella, Gonzalez Marie-Claude, Chettouh Zoubidda, Nicolini Alessia, Chabert Caroline, Smith Desmond J, Rubin Edward M, Migliore-Samour Danièle, Alleva Enrico
Abstract excerpt
Down syndrome is the most frequent genetic cause of mental retardation, having an incidence of 1 in 700 live births. In the present study we used a transgenic mouse in vivo library consisting of 4 yeast artificial chromosome (YAC) transgenic mouse lines, each bearing a different fragment of the Down syndrome critical region 1 (DCR-1), implicated in brain abnormalities characterizing this pathology. The 152F7...
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