Article
Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2008
Zhai Rihong, Liu Geoffrey, Zhou Wei, Su Li, Heist Rebecca Suk, Lynch Thomas J, Wain John C, Asomaning Kofi, Lin Xihong, Christiani David C
Abstract excerpt
PURPOSE: The vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving tumor growth and metastasis. Polymorphisms in the VEGF gene may regulate VEGF production. In this large case-control study, we investigated whether functional polymorphisms (-460C/T, +405C/G, +936...
Topics
- Aged
- Alleles
- Carcinoma, Non-Small-Cell Lung
- Case-Control Studies
- Cohort Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Lung Neoplasms
- Male
- Middle Aged