Article
Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2008
Zhai Rihong, Liu Geoffrey, Zhou Wei, Su Li, Heist Rebecca Suk, Lynch Thomas J, Wain John C, Asomaning Kofi, Lin Xihong, Christiani David C
Abstract excerpt
PURPOSE: The vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving tumor growth and metastasis. Polymorphisms in the VEGF gene may regulate VEGF production. In this large case-control study, we investigated whether functional polymorphisms (-460C/T, +405C/G, +936C/T) in the VEGF gene are associated with the risk of non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: VEGF...
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