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Article

Rapid determination of trisomy 21 from amniotic fluid cells using single-nucleotide polymorphic loci.

Prenatal diagnosis - 1 Dec 2005

Nagy Bálint, Bán Zoltán, Lázár Levente, Nagy Richárd Gyula, Papp Csaba, Tóth-Pál Erno, Papp Zoltán

Abstract excerpt

OBJECTIVES: Rapid detection of trisomy 21 is an important goal for prenatal genetic centers. Fluorescent-PCR and DNA fragment analysis was developed a decade ago and thousands of samples were analyzed in routine practice using this method. Quantitative real-time PCR with melting curve analysis using SNP markers for trisomy 21 detection was described recently. We studied the reliability of this method on a cohort...

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PMID: 16231333
DOI: 10.1002/pd.1288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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