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Article

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

3 Jul 2017

Abstract excerpt

Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/IGF-1 and glp-1/Notch mutants throughout adulthood. Our data are consistent with an age-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28675140
DOI: 10.7554/elife.18459

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