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Article

Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast.

Molecular biology of the cell - 1 Sept 2004

Gnann Andreas, Riordan John R, Wolf Dieter H

Abstract excerpt

Cystic fibrosis is the most widespread hereditary disease among the white population caused by different mutations of the apical membrane ATP-binding cassette transporter cystic fibrosis transmembrane conductance regulator (CFTR). Its most common mutation, DeltaF508, leads to nearly complete degr...

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Source

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Identifiers

PMID: 15215312
DOI: 10.1091/mbc.e04-01-0024
PMCID: PMC515346

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15215312-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast.PMID 15215312Read ↗

Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.Semantic proximity Read ↗

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.Semantic proximity Read ↗

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.Semantic proximity Read ↗

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Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic ReticulumSemantic proximity Read ↗

Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal.Semantic proximity Read ↗

The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.Semantic proximity Read ↗

Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi.Semantic proximity Read ↗

The multiple ubiquitination mechanisms in CFTR peripheral quality control.Semantic proximity Read ↗

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