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Article

N-glycosylation deficiency reduces ICAM-1 induction and impairs inflammatory response.

Glycobiology - 1 Apr 2014

He Ping, Srikrishna Geetha, Freeze Hudson H

Abstract excerpt

Congenital disorders of glycosylation (CDGs) result from mutations in various N-glycosylation genes. The most common type, phosphomannomutase-2 (PMM2)-CDG (CDG-Ia), is due to deficient PMM2 (Man-6-P → Man-1-P). Many patients die from recurrent infections, but the mechanism is unknown. We found th...

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Source

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Identifiers

PMID: 24474243
DOI: 10.1093/glycob/cwu006
PMCID: PMC3954120

Genes

MPI
PMM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24474243-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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