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Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detection

23 Jan 2008

Abstract excerpt

In an effort to improve affinity biomarker validation in fixed patient tissue specimens, we have developed a novel quantum dot-based bioimaging system that utilizes chicken IgY antibody for high sensitivity and specificity relative quantitation of cancer proteins. Monospecific, polyclonal IgYs were generated against human HER2 and telomerase, and analytically validated for specificity by western blot and...

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PMID: 18214859
DOI: 10.1002/ijc.23320

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