Article
Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma.
British journal of cancer - 12 Feb 2008
Slebos R J C, Li M, Vadivelu S, Burkey B B, Netterville J L, Sinard R, Gilbert J, Murphy B, Chung C H, Shyr Y, Yarbrough W G
Abstract excerpt
Carcinogen exposure from tobacco smoking is the major cause of upper aerodigestive tract cancer, yet heavy smokers only have about a 10% life-time risk of developing one of these cancers. Current technologies allow only limited prediction of cancer risk and there are no approved screening methods applicable to the general population. We developed a method to assess somatic mutational load using small-pool PCR...
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