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Article

Dyskerin Is a Component of the <i>Arabidopsis</i> Telomerase RNP Required for Telomere Maintenance

23 Jan 2008

Abstract excerpt

Dyskerin binds the H/ACA box of human telomerase RNA and is a core telomerase subunit required for RNP biogenesis and enzyme function in vivo. Missense mutations in dyskerin result in dyskeratosis congenita, a complex syndrome characterized by bone marrow failure, telomerase enzyme deficiency, and progressive telomere shortening. Here we demonstrate that dyskerin also contributes to telomere maintenance in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18212040
DOI: 10.1128/mcb.01490-07

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Dyskerin Is a Component of the <i>Arabidopsis</i> Telomerase RNP Required for Telomere MaintenancePMID 18212040Read ↗

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N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradationSemantic proximity Read ↗

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