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N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation

25 Mar 2019

Abstract excerpt

The telomerase holoenzyme responsible for maintaining telomeres in vertebrates requires many components in vivo, including dyskerin. Dyskerin binds and regulates the accumulation of the human telomerase RNA, hTR, as well as other non-coding RNAs that share the conserved H/ACA box motif. The precise mechanism by which dyskerin controls hTR levels is unknown, but is evidenced by defective hTR accumulation caused by...

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Share to RNA Interference and Gene Delivery
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Share to Telomeres, Telomerase, and Senescence

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PMID: 30931479
DOI: 10.1093/nar/gkz233

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N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradationPMID 30931479Read ↗

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Disease mutations in the N-terminal extension and α2’-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNASemantic proximity Read ↗

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Dyskerin is required for tumor cell growth through mechanisms that are independent of its role in telomerase and only partially related to its function in precursor rRNA processingSemantic proximity Read ↗

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