Article
Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa.
Oncotarget - 12 Jul 2016
Tahara Tomomitsu, Shibata Tomoyuki, Okubo Masaaki, Kawamura Tomohiko, Horiguchi Noriyuki, Ishizuka Takamitsu, Nakano Naoko, Nagasaka Mitsuo, Nakagawa Yoshihito, Ohmiya Naoki
Abstract excerpt
BACKGROUND: Telomere length shortening in Helicobacter pylori (H. pylori) infected gastric mucosa constitutes the earliest steps toward neoplastic transformation. In addition to this genotoxic changes, epigenetic changes such as promoter CpG island (PCGI) methylation are frequently occurred in H. pylori infected gastric mucosa. The aim of this study was to investigate a potential link between H. pylori related...
Topics
- Aged
- CpG Islands
- DNA Methylation
- Female
- Gastric Mucosa
- Genetic Predisposition to Disease
- Helicobacter Infections
- Helicobacter pylori
- Host-Pathogen Interactions
- Humans