Article
Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk.
Human molecular genetics - 1 May 2008
Chen Xiaowei, Weaver Joellen, Bove Betsy A, Vanderveer Lisa A, Weil Susan C, Miron Alexander, Daly Mary B, Godwin Andrew K
Abstract excerpt
The contribution of BRCA1 and BRCA2 to familial and non-familial forms of breast cancer has been difficult to accurately estimate because of the myriad of potential genetic and epigenetic mechanisms that can ultimately influence their expression and involvement in cellular activities. As one of these potential mechanisms, we investigated whether allelic imbalance (AI) of BRCA1 or BRCA2 expression was associated...
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