Article
Identification of BRCA1 and BRCA2 carriers by allele-specific gene expression (AGE) analysis.
International journal of cancer - 10 Apr 2002
Montagna Marco, Agata Simona, De Nicolo Arcangela, Menin Chiara, Sordi Gianni, Chieco-Bianchi Luigi, D'Andrea Emma
Abstract excerpt
Mutations in BRCA1 and BRCA2 genes confer a high risk of breast and ovarian cancer. As such, their identification is essential to reduce the risk of disease in healthy carriers, as well as in carriers who have already developed the disease because they are at increased risk for a second malignancy; moreover, noncarriers of BRCA1 and BRCA2 mutated families can be spared anxiety and unnecessary medical...
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