KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.

doi:10.1016/j.humimm.2008.04.005

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Article

KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.

Human immunology - 1 Jun 2008

Levinson Ralph D, Du Zeying, Luo Lihui, Holland Gary N, Rao Narsing A, Reed Elaine F, Rajalingam Raja

Abstract excerpt

Vogt-Koyanagi-Harada (VKH) disease is a putative autoimmune ocular inflammatory disease and is known to be associated with HLA-DR4 and -DR1 in Mestizos. We examined the genes encoding KIR receptors and human leukocyte antigen (HLA) class I ligands in patients with VKH disease and compared to published controls. We found trends toward more group B KIR haplogroups (p=0.059), with more activating KIR genes, in...

Topics

California
Female
Gene Frequency
Genetic Predisposition to Disease
HLA-DR Antigens
Haplotypes
Humans
Indians, North American
Male
Protein Interaction Domains and Motifs
Receptors, KIR
Uveomeningoencephalitic Syndrome

Source

Open in PubMed

Identifiers

PMID: 18571006
DOI: 10.1016/j.humimm.2008.04.005

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