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Article

Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease.

Investigative ophthalmology & visual science - 9 Sept 2011

Chu Mingliang, Yang Peizeng, Hu Ranran, Hou Shengping, Li Fuzhen, Chen Yuanyuan, Kijlstra Aize

Abstract excerpt

PURPOSE: Osteopontin (OPN) is a proinflammatory cytokine involved in chronic inflammatory diseases. This study aimed to analyze the role of OPN in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. METHODS: Serum levels of OPN in VKH patients and healthy controls were assayed by enzyme-linked immunosorbent assay (ELISA). Peripheral blood mononuclear cells (PBMCs) or CD4+ T cells were cultured with anti-CD3...

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PMID: 21810982
DOI: 10.1167/iovs.11-7539

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