Article
The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis.
Annals of the rheumatic diseases - 1 Oct 2008
Rueda B, Orozco G, Raya E, Fernandez-Sueiro J L, Mulero J, Blanco F J, Vilches C, González-Gay M A, Martin J
Abstract excerpt
OBJECTIVES: Recent results have shown that the IL23R gene, coding for a subunit of the interleukin-23 receptor, is strongly associated with autoimmunity. The aim of the current study was to investigate, for the first time, the possible involvement of the IL23R gene in genetic susceptibility to ankylosing spondylitis (AS). METHODS: We carried out a case-control association study in which 365 patients with AS and...
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