Article
Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jan 2008
Zhang X-F, Wang Y-M, Ge H, Cao Y-Y, Chen Z-F, Wen D-G, Guo W, Wang N, Li Y, Zhang J-H
Abstract excerpt
E-cadherin (CDH1) is a tumor suppressor involved in epithelial cell-cell interactions. Single nucleotide polymorphisms (SNP) in the CDH1 gene, -160C/A and -347G/GA in the 5'-promoter region and +54C/T in the 3'-untranslated region (UTR) have been shown to be associated with tumor development and progression via modifying transcriptional activity, mRNA stability or protein expression. To investigate the influence...
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