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Article

Changing effective population size and the McDonald-Kreitman test.

Genetics - 1 Dec 2002

Eyre-Walker Adam

Abstract excerpt

Artifactual evidence of adaptive amino acid substitution can be generated within a McDonald-Kreitman test if some amino acid mutations are slightly deleterious and there has been an increase in effective population size. Here I investigate the conditions under which this occurs. I show that fairl...

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Identifiers

PMID: 12524367
DOI: 10.1093/genetics/162.4.2017
PMCID: PMC1462352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12524367-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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