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Article

Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations.

Cellular and molecular life sciences : CMLS - 1 Mar 2008

Posey K L, Yang Y, Veerisetty A C, Sharan S K, Hecht J T

Abstract excerpt

Cartilage oligomeric matrix protein, also known as thrombospondin-5 (TSP-5), is an extracellular matrix protein found primarily in cartilage and musculoskeletal tissues. TSP-5 is of interest because mutations in the gene cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED/EDM1). Both PSACH and EDM1 have a characteristic chondrocyte phenotype distinguished by giant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18193163
DOI: 10.1007/s00018-007-7485-0
PMCID: PMC11131916

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations.PMID 18193163Read ↗

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